NanoBRIGHT has the long-term vision of developing novel cutting-edge optical approaches to study and treat pathological conditions of the brain without using genetically-encoded proteins. This will be achieved by developing a new generation of optical neural interfaces to bring plasmonics to the living brain. NanoBRIGHT seeks to develop low- invasiveness devices able to exploit unconventional combinations between optics and photonics to interact with the brain tissue, bringing light to control and monitor physiological phenomena not accessible with currently available techniques. This will generate ground-breaking new knowledge on brain diseases, as well as new technological paradigms for next generation devices to interface with the neural tissue without requirement for genetic modification.